Drug loading to mesoporous silica carriers by solvent evaporation: A comparative study of amorphization capacity and release kinetics

The sorption of poorly aqueous soluble active pharmaceutical ingredients (API) to mesoporous silica carriers is an increasingly common formulation strategy for dissolution rate enhancement this challenging group substances. However, the success approach a particular API depends on array factors including properties porous carrier, loading method, or attempted mass fraction API. At present, there no established methodology rational selection these parameters. In present work, we report systematic comparison four well-characterised and seven APIs loaded by same solvent evaporation method. each case, find maximum amorphization capacity x-ray powder diffraction analysis measure in vitro drug release kinetics. For selected also demonstrate potential bioavailability permeation essay.